2A,2B-Dihomo-15-alkyl-PGE1 analogs

ABSTRACT

2b, 2a-Dihomo-15-methyl and 15-ethyl PGF- and PGE-type compounds are disclosed with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

The present application is a division of Ser. No. 511,220, filed Oct. 2,1974, issued on Aug. 10, 1976 as U.S. Pat. No. 3,974,195.

The present invention relates to prostaglandin analogs, the essentialmaterial constituting a disclosure of which is incorporated here byreference from U.S. Pat. No. 3,974,195.

I claim:
 1. An optically active compound of the formula: ##STR1##wherein Z is ##STR2## and WHEREIN R₁ is hydrogen, alkyl of one to 12carbon atoms, inclusive, ##STR3## OR PHARMACOLOGICALLY ACCEPTABLE SALTSTHEREOF WHEN R₁ is hydrogen.
 2. A compound according to claim 1, whereinZ is ##STR4##
 3. 2a,2b-Dihomo-15(S)-15-methyl-PGE₁, a compound accordingto claim 2, wherein R₁ is hydrogen. 4.2A,2B-Dihomo-15(S)-15-methyl-PGE₁, methyl ester, a compound according toclaim 2, wherein R₁ is methyl.
 5. A compound according to claim 1,wherein Z is ##STR5##
 6. 2a,2b-Dihomo-15(R)-15-methyl-PGE₁, a compoundaccording to claim 5, wherein R₁ is hydrogen. 7.2A,2B-Dihomo-15(R)-15-methyl-PGE₁, methyl ester, a compound according toclaim 5, wherein R₁ is methyl.